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pSoBid: The psychological, social and biological determinants of ill health

pSoBid is a cross sectional population-based study which set out to investigate the psychological, behavioural and biological determinants of ill health.

Ill health has been long recognised as more prevalent in areas of relative social deprivation. Heart disease, diabetes, some cancers and rheumatoid arthritis are examples of the burden of ill health that is carried disproportionately by people from poorer circumstances. 

While much of this variation can be laid at the door of classical risk factors such as smoking, physical activity, poorer diets and so on, these factors fail to account for the totality of the variation. Social gradients are present in a range of biological and psychosocial variables which indicate that living in a deprived environment may increase the susceptibility to develop chronic diseases, through as of yet unknown mechanisms.

The pSoBid (pronounced 'so-bid') study sought to integrate established and new knowledge relating to the psychological, social, and biological determinants of health. The study brought together expertise from social epidemiology, public health, biochemistry, psychology, neuroscience and genetics, from the University of Glasgow, NHS Greater Glasgow and Clyde and the Glasgow Centre for Population Health, to build a better understanding of why living in poorer, more stressful circumstances results in higher levels of disease and ill health.

In a recruited cross-sectional group of participants from the least deprived and most deprived areas of Glasgow, pSoBid set out to:

• examine the associations between classical and novel risk factors and health outcomes, and to further examine the interactions between these determinants

• assess the extent to which the gap in health outcomes can be explained by these factors

• yield insights into new approaches which might help address Glasgow’s health record.

The pSoBid final report has been published and presents the full background to the study, a review of relevant literature, the complete study methodology and findings to date as a series of abstracts from published academic papers.

A Briefing Paper discussing the pSoBid study findings in relation to our understanding of health inequalities, implications for population health research and implications for policy and practice is also available.

 

Journal Articles

A number of academic journal articles have been published from the pSoBid study which are listed below:

 

openaccess new

Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study
Yoga N Velupillai, Chris J Packard CJ, G David Batty, Vladimir Bezylak, Harry Burns H, Jonathan Cavanagh, Kevin Deans, Ian Ford, Agnes McGinty, Keith Millar, Naveed Sattar, Paul Shiels, Carol Tannahill.
BMC Public Health 2008;8:126

 

openaccess newDifferences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population based study.
Kevin A Deans, Vladimir Bezylak, Ian Ford, G David batty, Harry Burns, Jonathan Cavanagh, Eric De Groot, Agnes McGinty, Keith Millar, Paul G Shiels, Carol Tannahill, Yoga N Velupillai, Naveed Sattar, Chris J Packard.
British Medical Journal 2009;339:b4170

 

openaccess newEarly life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive function: a cross-sectional, population based study.
Chris J Packard, Vladimir Bezylak, Jennifer S McLean, G David Batty, Ian Ford, Harry Burns, Jonathan Cavanagh, Kevin A Deans, Marian Henderson, Agnes McGinty, Keith Millar, Naveed Sattar, Paul G Shiels, Yoga N Velupillai, Carol Tannahill.
BMC Public Health 2011;11:42

 

openaccess newAccelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort.
Paul G Shiels, Lianne M McGlynn, Alan MacIntyre, Paul CD Johnson, G David Batty, Harry Burns, Jonathan Cavanagh, Kevin A Deans, Ian Ford, Alex McConnachie, Agnes McGinty, Jennifer S McLean, Keith Millar, Naveed Sattar, Carol Tannahill, Yoga N Velupillai, Chris J Packard.
PLoS ONE 2011; 6(7):e22521

 

Socio-economic status is associated with epigenetic differences in the pSoBid cohort. 
Dagmara McGuinness, Liane M McGlynn, Paul CD Johnson, Alan MacIntyre, David G Batty, Harry Burns, Jonathan Cavanagh, Kevin A Deans, Ian Ford, Alex McConnachie, Agnes McGinty, Jennifer S McLean, Keith Millar, Chris J Packard, Naveed A Sattar, Carol Tannahill, Yoga N Velupillai, Paul G Shiels
International Journal of Epidemiology 2012;1-10 

NOTE - this article is not Open Access and requires Athens or similar password for access 

 

openaccess newInteraction of personality traits with social deprivation
in determining mental wellbeing and health behaviours.

Chris J Packard, Jonathan Cavanagh, Jennifer S McLean, Alex McConnachie, Claudia Martina Messow, G David Batty, Harry Burns, Kevin A Deans, Naveed Sattar, Paul G Shiels, Yoga N Velupillai, Carol Tannahill, Keith Millar.
Journal of Public Health 2012, May 2, 1-10

 

25-Hydroxyvitamin D is lower in deprived groups, but is not associated with carotid intima media thickness or plaques: Results from pSoBid
Susan Knox, Paul Welsh, Vladimir Bezlyak, Alex McConnachie, Emma Boulton, Kevin A Deans, Ian Ford, G David Batty, Harry Burns, Jonathan Cavanagh, Keith Millar, Iain B McInnes, Jennifer S McLean, Yoga Velupillai, Paul Shiels, Carol Tannahill, Chris J Packard, A Michael Wallace, Naveed Sattar.
Atherosclerosis (2012), doi:10.1016/j.atherosclerosis.2012.05.001 

NOTE - this article is not Open Access and requires Athens or similar password for access

 

Early life socioeconomic status, chronic physiological stress and hippocampal N-acetyl aspartate concentrations. 
John McLean, Rajeev Krishnadas, G David Batty, Harry Burns, Kevin A Deans, Ian Ford, Alex McConnachie, Agnes McGinty, Jennifer S McLean, Keith Millar, Naveed Sattar, Paul G Shiels, Carol Tannahill, Yoga N Velupillai, Chris J Packard, Barry R Condon, Donald M Hadley, Jonathan Cavanagh. 
Behavioural Brain Research 2012, 235(2):225-30

NOTE - this article is not Open Access and requires Athens or similar password for access

 

openaccess newSoluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes
Ashley M Miller, David Purves, Alex McConnachie, Darren L Asquith, G David Batty, Harry Burns, Jonathan Cavanagh, Ian Ford, Jennifer S McLean, Chris J Packard, Paul G Shiels, Helen Turner, Yoga N Velupillai, Kevin A Deans, Paul Welsh, Iain B McInnes, Naveed Sattar
PLoS One 2012, 7(10):e47830

 

Personality, socio-economic status and inflammation: cross-sectional, population-based study
Keith Millar, Suzanne M. Lloyd, Jennifer S. McLean, G. David Batty, Harry Burns, Jonathan Cavanagh, Kevin A. Deans, Ian Ford, Alex McConnachie, Agnes McGinty, Rene Mottus, Chris J. Packard, Naveed Sattar, Paul G. Shiels, Yoga N. Velupillai1, Carol Tannahill. PLoS ONE 2013, 8(3):e58256

openaccess new

Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: Results from the psychological, social and biological determinants of ill health (pSoBid) study.
Rajeev Krishnadas, John McLean, David G. Batty, Harry Burns, Kevin A. Deans, Ian Ford,Alex McConnachie, Agnes McGinty, Jennifer S. McLean, Keith Millar, Naveed Sattar, Paul G. Shiels, Yoga N. Velupillai, Chris J. Packard, Jonathan Cavanagh. NeuroImage: Clinical 2013, 2(1):464-657

 

Socio-economic status and the cerebellar grey matter volume. Data from a well-characterised population sample.
Jonathan Cavanagh, Rajeev Krishnadas, G. David Batty, Harry Burns, Kevin A. Deans, Ian Ford, Alex McConnachie, Agnes McGinty, Jennifer S. McLean, Keith Millar, Naveed Sattar, Paul G. Shiels, Carol Tannahill, Yoga N. Velupillai, Chris J. Packard, John McLean.The Cerebellum 2013, DOI 10.1007/s12311-013-0497-4

NOTE - this article is not Open Access and requires Athens or similar password for access

 

Socio-economic deprivation and cortical morphology: Psychological, social and biological determinants of ill health study

Rajeev Krishnadas, John McLean, David G. Batty, Harry Burns, Kevin A. Deans, Ian Ford, Alex McConnachie, Jennifer S. McLean, Keith Millar, Naveed Sattar, Paul G. Shiels, Yoga N. Velupillai, Chris J. Packard, Jonathan Cavanagh. Psychosomatic Medicine 2013;75(7):616-623

NOTE - this article is not Open Access and requires Athens or similar password for access

openaccess new

The envirome and the connectome: exploring the structural noise in the human brain associated with socioeconomic deprivation.

Krishnadas R, Kim J, McLean J, Batty DG, McLean J, Millar K, Packard C, Cavanagh J. Frontiers in Human Neuroscience 2013, 7:722 DOI: 10.3389/fnhum.2013.00722